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The bioactivation of tramadol by CYP2D6 is an important supply of variability resulting from drug interaction. The analgesic efficacy of tramadol might be appreciably minimized by CYP2D6 inhibitors, for instance some SSRIs or terbinafine [114, one hundred fifteen].Depart the adaptor in the bottle and switch the bottle cap. Wash the syringe with h2o